Table 2 Genotype and allele distribution of MBL2 polymorphisms in dengue patients and healthy controls.
From: Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity
MBL2 polymorphisms | All patients n (%) | Dengue n (%) | DWS n (%) | Healthy controls n (%) | All patients vs. healthy controls | Dengue vs. healthy controls | DWS vs. healthy controls | |||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||
rs11003125 (− 550C/G) | ||||||||||
CC (LL) | 77 (33.0) | 53 (37.3) | 24 (26.4) | 40 (23.5) | Reference | Reference | Reference | |||
GC (HL) | 95 (40.8) | 52 (36.6) | 43 (47.3) | 76 (44.7) | NS | NS | NS | |||
GG (HH) | 61 (26.2) | 37 (26.1) | 24 (26.4) | 54 (31.8) | NS | NS | NS | |||
C (L) | 249 (53.4) | 158 (55.6) | 91 (50) | 156 (45.9) | Reference | Reference | Reference | |||
G (H) | 217 (46.6) | 126 (45.4) | 91 (50) | 184 (54.1) | 0.6 (0.37–0.95) | 0.03 | NS | NS | ||
rs7096206 (− 221 G/C,A) | ||||||||||
CC (XX) | 152 (56.5) | 97 (59.1) | 55 (52.4) | 99 (55.6) | Reference | Reference | Reference | |||
CG(A) (XY) | 94 (34.9) | 53 (32.3) | 41 (39.0) | 66 (37.1) | NS | NS | NS | |||
GG (YY) | 23 (8.6) | 14 (8.5) | 9 (8.6) | 13 (7.3) | NS | NS | NS | |||
C (X) | 398 (74) | 247 (75.3) | 151 (71.9) | 264 (74.9) | Reference | Reference | Reference | |||
G (Y) | 140 (26) | 81 (24.7) | 59 (28.1) | 92 (25.1) | NS | NS | NS | |||
rs7095891 (+ 4G/A) | ||||||||||
GG (PP) | 233 (84.1) | 143 (83.6) | 90 (84.9) | 169 (86.2) | Reference | Reference | Reference | |||
GA (PQ) | 42 (15.1) | 28 (16.4) | 14 (13.1) | 25 (12.8) | NS | NS | NS | |||
AA (QQ) | 2 (0.7) | 0 (0) | 2 (1.9) | 2 (1.0) | NS | NS | NS | |||
G (P) | 508 (91.7) | 314 (91.8) | 194 (91.5) | 363 (92.6) | Reference | Reference | Reference | |||
A (Q) | 46 (8.3) | 28 (8.2) | 18 (8.5) | 29 (7.4) | NS | NS | NS | |||
MBL2*Exon1 (codon 54) G>A | ||||||||||
GG | 161 (59.7) | 96 (58.2) | 64 (62.1) | 140 (78.2) | Reference | Reference | Reference | |||
GA | 103 (38.8) | 67 (40.6) | 37 (35.9) | 38 (21.2) | 2.6 (1.4–5.1) | 0.004 | 2.4 (1.1–5.5) | 0.034 | 2.9 (1.2–6.9) | 0.018 |
AA | 4 (1.5) | 2 (1.2) | 2 (1.9) | 1 (0.6) | NS | NS | NS | |||
G | 425 (79.3) | 260 (78.8) | 165 (80.1) | 318 (88.8) | Reference | Reference | Reference | |||
A | 111 (20.7) | 70 (21.2) | 41 (19.9) | 40 (11.2) | 2.1 (1.2–3.8) | 0.012 | 1.99 (1–4.1) | 0.05 | 2.2 (1.05–4.8) | 0.037 |
MBL2*Exon1 codons 52 + 54 + 57 | ||||||||||
AA | 161 (59.7) | 96 (58.2) | 64 (62.1) | 137 (76.5) | Reference | Reference | Reference | |||
AO | 103 (38.8) | 67 (40.6) | 37 (35.9) | 41 (22.9) | 2.4 (1.3–4.7) | 0.008 | 2.2 (1.0 − 5.1) | 0.05 | 2.7 (1.1–6.4) | 0.027 |
OO | 4 (1.5) | 2 (1.2) | 2 (1.9) | 1 (0.6) | NS | NS | NS | |||
A | 425 (79.3) | 260 (78.8) | 165 (80.1) | 315 (88) | Reference | Reference | Reference | |||
O | 111 (20.7) | 70 (21.2) | 41 (19.9) | 43 (12) | 1.97 (1.1–3.5) | 0.021 | NS | 2.1 (1–4.5) | 0.05 | |
