Table 6 Correlation of complement proteins with clinical parameters in dengue patients.

From: Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity

 

C2 (µg/ml)

C4b (µg/ml)

C5 (µg/ml)

C5a (µg/ml)

C9 (µg/ml)

Factor D (µg/ml)

MBL (µg/ml)

Factor I (µg/ml)

AST (IU/ml)

ALT (IU/ml)

RBC (× 103/ml)

WBC (× 106/ml)

PLT (× 103/ml)

HCT (%)

C2 (µg/ml)

rs

 

0.5

0.39

0.61

0.052

− 0.25

0.004

0.02

0.14

0.13

− 0.09

0.16

0.07

− 0.12

P

 

< 0.0001

< 0.0001

< 0.0001

0.51

0.002

0.96

0.79

0.09

0.11

0.27

0.04

0.38

0.14

C4b (µg/ml)

rs

0.35

 

0.52

0.38

0.08

− 0.15

− 0.09

0.19

− 0.1

− 0.04

− 0.15

0.06

0.25

− 0.12

P

< 0.0001

 

< 0.0001

< 0.0001

0.29

0.06

0.23

0.014

0.22

0.66

0.053

0.45

0.002

0.15

C5 (µg/ml)

rs

0.17

0.37

 

0.37

0.32

0.04

− 0.11

0.12

0.03

0.003

0.03

0.09

0.03

0.03

P

0.08

< 0.0001

 

< 0.0001

< 0.0001

0.58

0.16

0.45

0.69

0.97

0.72

0.23

0.76

0.76

C5a (µg/ml)

rs

0.62

0.32

0.34

 

− 0.17

− 0.34

0.07

− 0.06

0.16

0.1

0.02

0.06

− 0.03

0.01

P

< 0.0001

0.001

0.001

 

0.03

< 0.0001

0.39

0.46

0.64

0.23

0.81

0.43

0.67

0.9

C9 (µg/ml)

rs

− 0.24

− 0.14

0.18

− 0.31

 

0.21

− 0.05

0.12

− 0.044

− 0.001

0.015

− 0.02

0.09

0.005

P

0.02

0.18

0.08

0.002

 

0.01

0.51

0.12

0.6

0.99

0.86

0.79

0.26

0.95

Factor D (µg/ml)

rs

− 0.5

− 0.23

0.09

− 0.53

0.49

 

− 0.17

0.145

0.09

0.06

0.31

− 0.24

− 0.31

0.32

P

< 0.0001

0.03

0.39

< 0.0001

< 0.0001

 

0.034

0.69

0.34

0.61

< 0.0001

0.002

< 0.0001

< 0.0001

MBL (µg/ml)

rs

0.18

0.06

0.11

0.16

− 0.17

− 0.12

 

− 0.04

− 0.01

0.01

− 0.08

− 0.05

0.11

− 0.02

P

0.07

0.54

0.29

0.11

0.09

0.23

 

0.59

0.9

0.94

0.31

0.58

0.17

0.71

Factor I (µg/ml)

rs

0.12

0.29

0.24

− 0.05

0.09

0.25

0.06

 

− 0.13

− 0.15

− 0.08

− 0.005

0.15

− 0.1

P

0.23

0.004

0.02

0.62

0.38

0.01

0.53

 

0.14

0.06

0.34

0.95

0.065

0.24

AST (IU/ml)

rs

0.27

0.07

− 0.02

0.22

− 0.18

− 0.25

− 0.12

0.02

 

0.87

0.28

− 0.03

− 0.46

0.23

P

0.012

0.54

0.88

0.04

0.09

0.02

0.29

0.8

 

< 0.0001

< 0.0001

0.75

< 0.0001

0.005

ALT (IU/ml)

rs

0.32

0.14

− 0.001

0.3

− 0.27

− 0.25

− 0.03

0.04

0.91

 

0.27

0.09

− 0.34

0.21

P

0.002

0.2

0.99

0.005

0.01

0.015

0.8

0.7

< 0.0001

 

0.001

0.27

< 0.0001

0.008

RBC (× 103/ml)

rs

0.11

− 0.22

0.03

0.03

0.04

0.18

0.02

0.05

0.001

0.07

 

0.006

− 0.3

0.87

P

0.28

0.03

0.79

0.8

0.7

0.08

0.85

0.66

0.99

0.5

 

0.94

< 0.0001

< 0.0001

WBC (× 106/ml)

rs

0.24

0.04

0.02

0.25

− 0.23

− 0.16

0.18

0.25

0.26

0.36

0.25

 

0.26

0.04

P

0.02

0.7

0.86

0.012

0.02

0.11

0.07

0.014

0.013

< 0.0001

0.009

 

< 0.0001

0.61

PLT (× 103/ml)

rs

− 0.08

0.14

0.11

0.05

− 0.05

− 0.22

− 0.07

− 0.05

− 0.1

− 0.007

− 0.26

− 0.09

 

− 0.28

P

0.43

0.14

0.29

0.6

0.6

0.026

0.5

0.63

0.32

0.94

0.006

0.36

 

< 0.0001

HCT (%)

rs

0.004

− 0.24

0.03

− 0.07

− 0.04

0.18

− 0.02

0.05

0.04

0.08

0.86

0.26

− 0.32

 

P

0.97

0.17

0.78

0.68

0.68

0.067

0.87

0.6

0.7

0.4

< 0.0001

0.006

0.001

 
  1. Spearman’s rho (rs) calculated by Spearman's rank correlation coefficient. rs and P values in the upper-right area are the correlation between variables in dengue patients. rs and P values in the lower-left area are the correlation between variables in dengue patients with warning signs (DWS).
  2. Bold rs and P values indicate a significant and strong correlation between variables.
  3. AST and ALT aspartate and alanine amino transferase, WBC white blood cells, RBC red blood cells, PLT platelets, HCT haematocrit, IU international unit.