Figure 6 | Scientific Reports

Figure 6

From: Formalin-fixed paraffin-embedded renal biopsy tissues: an underexploited biospecimen resource for gene expression profiling in IgA nephropathy

Figure 6The alternative text for this image may have been generated using AI.

TNFAIP6, DEFA4, and CXCL6 urinary levels in IgAN. (A) Urinary TNFAIP6 levels are significantly higher in IgAN patients with active renal lesions compared to other groups (n = 34 active group, n = 17 chronic, n = 23 non-IgAN, n = 17 LN and VS and n = 14 HBD). ANOVA F(4,94) = 6.246 p = 0.0002; Tukey’s multiple comparison test, active versus all p < 0.05. (B) High urinary DEFA4 levels are present in both active and chronic renal lesion groups, and these levels are significantly higher compared to non-IgAN, LN-VS and HBD (n = 34 active group, n = 17 chronic, n = 23 non-IgAN, n = 17 LN and VS and n = 14 HBD. ANOVA F(4,94) = 5.759 p = 0.0003; Tukey’s multiple comparison test, active versus and chronic versus HBD p < 0.05. (C) Urinary CXCL6 levels are significantly higher in IgAN patients with chronic renal lesions compared to the other groups (n = 34 active group, n = 17 chronic, n = 23 non IgAN, n = 17 LN and VS and n = 14 HBD. Kruskal–Wallis test p value = 0.0002. Dunn’s multiple comparison test, chronic versus all groups p < 0.05, (D) TNFAIP6/CXCL6 ratio is able to predict patients characterized by active or chronic renal lesions using a receiver operating characteristic curve (ROC) analysis. The area under the curve (AUC) was 0.78 (n = 33 active, n = 17 chronic as controls, 95% confidence interval 0.648–0.9156, p = 0.0009), a cut-off value of 33.25 had the highest sensitivity 83.33% (95% CI 61–94) and specificity 73% (95% CI 56–85).

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