Figure 4
From: Alteration of gene expression in mice after glaucoma filtration surgery
Schematic summary of microarray analysis. We found hyperexpression of keratinization-related genes (Krt16, Sprr1b) and of gene expression (Il1b) in response to external stimuli (tissue injury). Hyperexpression of inflammatory response-related genes (Il6, Saa1, S100a8) and genes related to the chemotaxis of inflammatory cells (Cxcl1, Cxcl5, Ccl2) was also observed. On the other hand, hypoexpression of the goblet cell marker (Gp2) suggests breakdown of epithelial homeostasis. We also found upregulation of keratinization-related transcripts (Krt1, Lor, Hrnr) and downregulation of muscle tissue-related transcripts (Eln, Myh3, Myl4) after MMC treatment of the bleb region.
