Table 2 Best performing medication scores evaluated in three separate validation datasets by C-index and Negelkerke R2.
From: A data-driven medication score predicts 10-year mortality among aging adults
Score derivation method | Number of medications included | Main cohort FINRISK validation subset | Replication cohorts | ||||
|---|---|---|---|---|---|---|---|
R2 | C-index ∆C baseline | ||||||
R2 | C-index (95% CI) ∆C baseline (95% CI) | H2000 | Estonia | H2000 | Estonia | ||
Baseline model (age and sex) | – | 0.134 | 0.766 (0.745–0.788) | 0.309 | 0.098 | 0.823 | 0.775 |
Expert consensus panel | 166 | 0.149 | 0.779 (0.758–0.800) | 0.316 | 0.107 | 0.827 | 0.786 |
+ 0.013 (0.006–0.019) | + 0.004 | + 0.011 | |||||
Number of medications | 301 | 0.148 | 0.777 (0.756–0.798) | 0.317 | 0.104 | 0.828 | 0.785 |
+ 0.011 (0.005–0.017) | + 0.005 | + 0.010 | |||||
Shotgun stochastic search | 8 | 0.158 | 0.785 (0.764–0.806) | 0.317 | 0.102 | 0.827 | 0.781 |
+ 0.019 (0.01–0.027) | + 0.004 | + 0.006 | |||||
Cox LASSO | 65 | 0.164 | 0.791 (0.771–0.812) | 0.324 | 0.109 | 0.830 | 0.793 |
+ 0.025 (0.017–0.033) | + 0.007 | + 0.018 | |||||
Cox LASSO signs only | 65 | 0.162 | 0.791 (0.770–0.811) | 0.320 | 0.110 | 0.829 | 0.791 |
+ 0.025 (0.017–0.032) | + 0.006 | + 0.016 | |||||
Ridge regression | 301 | 0.164 | 0.793 (0.772–0.813) | 0.322 | 0.113 | 0.830 | 0.795 |
+ 0.026 (0.018–0.034) | + 0.007 | + 0.020 | |||||
Elastic net | 214 | 0.166 | 0.794 (0.773–0.814) | 0.324 | 0.108 | 0.830 | 0.784 |
+ 0.028 (0.019–0.036) | + 0.007 | + 0.009 | |||||
