Table 7 Differentially methylated regions (DMRs) and associated CpGs found using DMRcate with a threshold p = 10−6.
From: Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study
Genomic location | Number of CpGs | Nearby Gene | CpG site | Estimated average participant causal effect (APCE) | Fisher exact paired p-valuea |
|---|---|---|---|---|---|
chromosome3 (146261941–146262421) | 6 | PLSCR1 | cg05452836 | 0.0284 − 0.0250 = 0.0034 | 0.0083 |
cg10679755 | 0.0252 − 0.0212 = 0.0040 | 0.0187 | |||
cg12662193 | 0.0346 − 0.0257 = 0.0089 | 0.0004 | |||
cg14795253 | 0.0287 − 0.0226 = 0.0061 | 0.0012 | |||
cg15437043 | 0.2160 − 0.2143 = 0.0017 | 0.8154 | |||
cg23486067 | 0.0258 − 0.0194 = 0.0064 | 0.0154 | |||
Chromosome 12 (123215010–123215308) | 7 | HCAR1 | cg00357958 | 0.4270 − 0.4037 = 0.0234 | 0.0034 |
cg01306688 | 0.2559 − 0.2356 = 0.0203 | 0.1680 | |||
cg05290737 | 0.3522 − 0.3328 = 0.0194 | 0.0153 | |||
cg19975916 | 0.2122 − 0.1987 = 0.0135 | 0.2715 | |||
cg20566840 | 0.3998 − 0.4294 = 0.0296 | 0.0428 | |||
cg22534509 | 0.3834 − 0.3560 = 0.0274 | 0.0135 | |||
cg22972858 | 0.4241 − 0.4025 = 0.0216 | 0.0068 | |||
Chromosome 6 (33560953–33561449) | 9 | LINC00336 | cg00536532 | 0.6582 − 0.6683 = − 0.0100 | 0.2623 |
cg01392313 | 0.1600 − 0.1315 = 0.0284 | 0.0015 | |||
cg04329454 | 0.2349 − 0.2018 = 0.0331 | 0.0039 | |||
cg05602975 | 0.1069 − 0.0978 = 0.0091 | 0.0877 | |||
cg06289138 | 0.1711 − 0.1535 = 0.0176 | 0.0949 | |||
cg07873320 | 0.1926 − 0.1852 = 0.0073 | 0.1752 | |||
cg08301503 | 0.1479 − 0.1276 = 0.0203 | 0.0015 | |||
cg19735538 | 0.0763 − 0.0644 = 0.0118 | 0.1153 | |||
cg19869469 | 0.1632 − 0.1454 = 0.0178 | 0.0007 |
