Figure 5 | Scientific Reports

Figure 5

From: Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial

Figure 5

Functional contribution of Test product strains to the gut microbiome and their association with resident species. (A) Ranked barplot of 50 of 798 KOs with the highest relative abundance contributions. NA corresponds to unclassified KOs. (B) Ranked barplot of the distribution of the 798 KOs within transporter and enzyme KEGG BRITE category. The colors indicate the most dominant functions. (C) Microbial co-abundance network based on the SPIEC-EASI method. Each dot represents a single MSPs. Positively and negatively co-abundant MSPs are connected by blue and red lines, respectively, the thickness of which is determined by weight in the SPIEC-EASI, model. Node colors indicate the number of shared specific functions from a list of 798 KOs contributed by the Test product probiotic candidate species (Lactobacillus rhamnosus and Lactobacillus paracasei) to the gut microbiota. Node diameter indicates the geodesic edge distance with MSPs. D. Barplot of the number of shared contributive KOs between Test product strains and dominant species as a function of geodesic distance extracted from the abundance co-variation network.

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