Table 2 Percentages of CD45 + immune cells in control and noise-exposed cochleae.

From: The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells

Immune cell

Control

Noise exposed

P values

Day 1

Day 4

Day 7

Day 14

M + F

M + F

M + F

M + F

M + F

Lymph + LiveCD45 + 

6.53 ± 2.17

5.03 ± 0.91

7.35 ± 1.95

6.85 ± 1.95

12.15 ± 2.80 (*P = 0.01)

p = 0.00040 (D1 vs 14)

p = 0.021 (D4 vs 14)

p = 0.01 (D7 vs 14)

Lymph + LiveCD45 + B220 + (B cell)

5.59 ± 2.24

11.59 ± 4.40 (*p = 0.038)

6.41 ± 2.22

12.95 ± 5.29 (*p = 0.01)

8.38 ± 2.08

p = 0.05 (D1 vs4)

p = 0.014 (D4 vs 7)

Lymph + LiveCD45 + CD3e + (T cell)

3.56 ± 0.92

3.97 ± 2.56

5.00 ± 1.27

6.65 ± 2.94

4.35 ± 1.05

NS

Lymph + LiveCD45 + NK1.1 + (NK cell)

14.69 ± 3.73

19.98 ± 6.79

16.64 ± 4.02

22.32 ± 7.69

26.38 ± 5.77

NS

Lymph + LiveCD45 + CD11b + (myeloid cell)

33.13 ± 7.44

22.44 ± 5.11

28.14 ± 6.12

36.32 ± 6.34

48.18 ± 7.80 (*p = 0.046)

p = 0.00007 (D1 vs 14)

p = 0.05 (D1 vs 7)

p = 0.001 (D4 vs 14)

Lymph + LiveCD45 + CD11b + CXC3R1 + (Macrophages)

7.05 ± 3.37

8.60 ± 3.55

10.03 ± 3.03

8.79 ± 2.56

15.86 ± 4.93 (*p = 0.024)

 

Lymph + LiveCD45 + CD11b + Ly6G + CD11c-(neutrophils)

1.50 ± 1.03

7.16 ± 3.54 (*p = .001)

2.97 ± 1.06

1.78 ± 0.41

1.45 ± 0.55

p = 0.016 (D 1 vs 4)

p = 0.001 (D1 vs 7)

p = .001 (D1 vs 14)

  1. Immune cells (B, T, NK, myeloid cells, macrophages, and neutrophils) population in the control and noise- exposed cochleae has been shown as the percentage population of the total CD45 + cells. Percentage population of CD45 + cells are from the total pool of live lymphocytes in the cochleae. Data are shown as mean ± SEM. A p value of < 0.05 was considered as significant. All the p values shown here are compared to control cochleae. *Control vs days. M male, F female, NS not significant.
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