Figure 3 | Scientific Reports

Figure 3

From: A serial multiparametric quantitative magnetic resonance imaging study to assess proteoglycan depletion of human articular cartilage and its effects on functionality

Figure 3The alternative text for this image may have been generated using AI.

Details of a high-concentration trypsin-treated cartilage sample, its response to loading, and corresponding histological sections. Serial quantitative T1 (a), T1ρ (b), T2 (c), and T2* (d) maps as well as corresponding histological sections (e) of a representative sample before and after exposure to high concentration of trypsin at 1.0 mg/mL for 2 h. Histological assessment revealed intact tissue surface and tidemark as well as regular cellularity (e1), but expansive Safranin-O de-staining indicative of advanced proteoglycan depletion of the superficial und transitional tissue zones (e2). Superficial artefacts secondary to histological preparation. Otherwise, image details as in Fig. 1.

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