Figure 5
From: Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model
Markers of central sensitization were not altered in the OA post-traumatic DMM model. The protein levels of c-Fos (A), p-ERK1/2 (B), GFAP (C) and IBA-1 (D) were quantified in the spinal cord of the DMM mice 12 weeks after surgery by western blot. The p-ERK1/2 expression was normalized to ERK1/2, and the c-Fos, GFAP and IBA-1 expression were normalized to the GAPDH. No differences were observed in the expression levels of both markers between DMM and sham-operated mice. Results are presented as mean ± SEM, n = 5 per group.
