Table 1 The association of disease onset sites with rates of disease progression.

From: Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis

 

Fast (N = 48, 48.0%)

Slow (N = 52, 52.0%)

p-value (Fisher or Wilcox test)

Onset site

Arm

24 (54.5)

20 (45.5)

 

Leg

7 (25.0)

21 (75.0)

 

Bulbar

17 (68.0)

8 (32.0)

 

Other

0 (0)

3 (100)

0.002

Age at first symp

Mean (SD)

58.4 (11.9)

58.7 (11.7)

 

Median [IQR] (range)

59 (50, 67] (32.5, 80.9)

59 (52, 68] (30.2, 79.3)

0.948

Age at DX

60.5 (11.5)

60.7 (11.7)

 

61 (54, 69] (33.1, 82.5)

61 (54, 69] (32.2, 81.4)

0.947

  1. Patients with bulbar onset exhibit faster rates of disease progression while patients with leg onset more often have slower rates of progression. There is no association between the age of the patient at symptom onset and the rate of disease progression.
  2. SD standard deviation, IQR interquartile range, DX diagnosis.
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