Table 1 Gross morphology, micromanometry and echocardiography post-SAC.

	Sham	SAC	p-value
Gross morphology	n = 7	n = 6
BW (g)	22.29 ± 1.1	21.92 ± 1.17	0.566	ns
HW (mg)	117 ± 11.37	161.5 ± 10.85	P < 0.0001	****
LV weight (mg)	77.66 ± 7.06	111.4 ± 6.68	P < 0.0001	****
TL (mm)	16.03 ± 0.34	15.61 ± 0.59	0.131	ns
Lungs (mg)	135.2 ± 10.7	126.5 ± 8.3	0.134	ns
HW/BW (mg/g)	5.26 ± 0.51	7.39 ± 0.65	P < 0.0001	****
Lungs/TL (mg/mm)	8.44 ± 0.69	8.57 ± 1.35	0.82	ns
Micromanometry	n = 19	n = 17
HR (bpm)	494 ± 15	490 ± 17	0.282	ns
MAP (mmHg)	88 ± 8	108 ± 6	P < 0.0001	****
LV dP/dt_max (mmHg/S)	11,491 ± 1746	11,048 ± 1912	0.473	ns
LV dP/dt_min (mmHg/S)	− 8,044 ± 1,268	− 7,695 ± 1589	0.469	ns
LVSP (mmHg)	107 ± 8	145 ± 12	P < 0.0001	****
LVEDP (mmHg)	7.7 ± 2.45	9.6 ± 3	0.039	*
LV HR (bpm)	492 ± 12	481 ± 21	0.447	ns
Echocardiography	n = 10	n = 9
HR (bpm)	501 ± 48	478 ± 42	0.3	ns
LVEDV (mm³)	27.6 ± 2.9	28.3 ± 5.7	0.745	ns
SV (µl)	24.9 ± 2.1	23.1 ± 3.5	0.186	ns
CO (ml/min)	12.5 ± 1.7	11 ± 1.4	0.054	ns
h_end-diastole (mm)	1.026 ± 0.069	1.221 ± 0.092	P < 0.0001	****
R_end-diastole (mm)	1.54 ± 0.076	1.54 ± 0.143	0.935	ns
h_end-systole (mm)	1.614 ± 0.256	1.775 ± 0.186	0.14	ns
R_end-systole (mm)	0.498 ± 0.151	0.681 ± 0.225	0.068	ns
h/R_end-systole (mm)	3.707 ± 1.224	2.987 ± 1.445	0.256	ns
ESP (2 × SAP + DAP)/3	100 ± 5	132 ± 9	P < 0.0001	****
LVEDWS (LVEDP × R_end-diastole / 2 × h_end-diastole)	6.05 ± 2.34	6.41 ± 1.93	0.78	ns

Gross morphology, micromanometry, and echocardiography from adult male C57BL/6J mice (9-week-old) at one week post-sham or -SAC surgery. Data are presented as mean ± SD; independent comparisons were made by two-tailed Student’s unpaired t-tests; *P < 0.05, **P < 0.01, and ****P < 0.0001 and ns, non-significant.
BW body weight, HW heart weight, TL tibia length, HR heart rate, MAP mean aortic pressure, dP/dt_max maximal rate of contractility, dP/dt_min minimal rate of contractility, LVSP LV systolic pressure, LVEDP end-diastolic blood pressure, LVEDV LV end-diastolic volume, SV stroke volume, CO cardiac output, h LV wall thickness, R LV internal chamber radius, LVESP LV end-systolic pressure, LVEDWS LV end-diastolic wall stress.

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