Table 2 Kinetic parameters of HDL-apoA-I subclasses in fasted and fed states.

From: Effect of fasting and feeding on apolipoprotein A-I kinetics in preβ1-HDL, α-HDL, and triglyceride-rich lipoproteins

Parameters

Fasted state

Fed state

Conversion preβ1 → α-HDL (pool/day)

85.40 ± 12.68

66.56 ± 14.72

Conversion α → preβ1-HDL (pool/day)

4.46 ± 1.48

4.70 ± 0.91

Preβ1-HDL-apoA-I FCR (pool/day)

0.45 ± 0.07

0.23 ± 0.04*

α-HDL-apoA-I FCR (pool/day)

0.29 ± 0.03

0.34 ± 0.03

Preβ1-HDL-apoA-I pool size (mg/kg)

6.94 ± 1.17

7.21 ± 0.50

α-HDL-apoA-I pool size (mg/kg)

54.47 ± 1.44

52.94 ± 5.69

Hepatic apoA-I APR (mg/kg/day)

18.67 ± 1.69

17.17 ± 2.75

Intestinala apoA-I APR (mg/kg/day)

–

2.20 ± 0.61

Total apoA-I APR (mg/kg/day)

18.67 ± 1.69

19.37 ± 2.47

  1. Data from six healthy subjects are shown as mean ± SD for each state. *p < 0.05 between fasted and fed state.
  2. HDL, high-density lipoprotein; FCR, fractional catabolic rate; APR, absolute production rate.
  3. aEstimate of intestinal apoA-I production related to feeding. This value does not account for a basal secretion from the enterocytes in a fasted condition.
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