Figure 4
From: Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats
Percentage of relaxation in pulmonary arteries in response to 10–5 M concentration of ACh under different experimental conditions; (A) control conditions, (**), p < 0.01, ApoE KO-western diet vs ApoE KO-control diet; (B) incubation for 20 min with non-selective inhibitor of NO synthase, 100 µML-NAME, (**), p < 0.001, ApoE KO-Western diet vs ApoE KO-standard diet; (C) incubation for 20 min with both L-NAME and 3 µM indomethacin, (**), p < 0.001, ApoE KO-standard diet vs Sprague Dawley ; (D) 20 min incubation with Cocktail: L-NAME, indomethacin, TRAM-34 and apamin, i.e. pharmacological inhibition of all major pathways for endothelium-dependent relaxation. ANOVA, n = 8, 7.
