Figure 7
From: Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats
ACh concentration–response curves of mesenteric arteries from different experimental groups under; control conditions; after 20 min incubation with non-selective inhibitor of NO synthase, L-NAME (100 µM); after the incubation with both L-NAME (100 µM) and indomethacin (3 µM); after 20 min incubation with Cocktail: L-NAME, indomethacin, TRAM-34 and apamin, i.e. pharmacological inhibition of all major pathways for endothelium-dependent relaxation; (**), P < 0.001, effect of L-NAME; (+ +), P < 0.001, effect of indomethacin, (xx), P < 0.001, effect of Cocktail, n = 8, n = 7.
