Figure 1 | Scientific Reports

Figure 1

From: Early-stage knee OA induced by MIA and MMT compared in the murine model via histological and topographical approaches

Figure 1

Typical MIA and MMT effect on the cartilage with Toluidine Blue and Red Sirius stainings. On Toluidine Blue slices, MIA shows a tibial cartilage loss of intensity with a loss of proteoglycans for all three zones, and affects surface integrity. MMT shows a loss of proteoglycans in the outer third of the femoral cartilage. Scale bar = 0.5 mm. On Red Sirius slices, in comparison with healthy samples on white light, MIA shows higher intensity in the superficial zone in femoral lateral cartilage and disorganization in tibial lateral cartilage. MMT shows higher intensity on the outer third of the femoral medial cartilage. A quantitative analysis of intensity for polarized views can be found in Fig. 3. Scale bar = 0.25 mm.

Back to article page