Table 3 Hazard ratios for varying histories of diabetes in the family for incident cardiovascular diseases (CVD), stroke and myocardial infarction (MI).
Hazard Ratioa (95% CI) | EPIC-potsdam (n ~ 26,054) | CARLA (n = 1,079) | SHIP (n = 3,974) | KORA (n = 11,781) | Pooled estimate b |
|---|---|---|---|---|---|
Outcome: CVD | |||||
Parental history of diabetes | 1.03 (0.83–1.29) | 0.68 (0.37–1.24) | 0.96 (0.75–1.24) | 1.00 (0.86–1.17) | 0.99 (0.88–1.10) |
Maternal history | 1.13 (0.91–1.40) | 0.72 (0.37–1.42) | 0.98 (0.75–1.28) | 1.05 (0.89–1.24) | 1.05 (0.93–1.18) |
Paternal history | 0.90 (0.64–1.27) | 1.15 (0.52–2.53) | 1.03 (0.68–1.55) | 0.95 (0.75–1.21) | 0.96 (0.81–1.14) |
Sibling history | 1.43 (0.94–2.17) | 1.58 (0.90–2.78) | 1.04 (0.73–1.47) | – | 1.25 (0.97–1.61) |
Family history | 1.14 (0.92–1.40) | 1.12 (0.69–1.82) | 0.92 (0.73–1.16) | – | 1.04 (0.90–1.21) |
Outcome: MI | |||||
Parental history of diabetes | 1.17 (0.87–1.59) | 0.55 (0.23–1.30) | 1.07 (0.79–1.44) | 1.06 (0.88–1.29) | 1.07 (0.92–1.23) |
Maternal history | 1.26 (0.93–1.72) | 0.53 (0.19–1.49) | 1.13 (0.81–1.56) | 1.09 (0.88–1.34) | 1.12 (0.96–1.30) |
Paternal history | 1.08 (0.71–1.66) | 0.82 (0.25–2.67) | 0.85 (0.50–1.45) | 1.00 (0.74–1.35) | 0.99 (0.79–1.23) |
Sibling history | 1.60 (1.01–2.54) | 1.24 (0.56–2.76) | 1.28 (0.84–1.94) | – | 1.39 (1.04–1.86) |
Family history | 1.34 (1.02–1.75) | 0.83 (0.42–1.64) | 1.03 (0.78–1.37) | – | 1.14 (0.90–1.44) |
Outcome: Stroke | |||||
Parental history of diabetes | 0.91 (0.68–1.22) | 0.87 (0.38–2.03) | 0.89 (0.60–1.32) | 1.09 (0.90–1.33) | 1.00 (0.86–1.16) |
Maternal history | 1.02 (0.76–1.37) | 0.98 (0.40–2.39) | 0.87 (0.57–1.33) | 1.10 (0.88–1.37) | 1.04 (0.88–1.22) |
Paternal history | 0.72 (0.41–1.26) | 1.73 (0.58–5.11) | 1.46 (0.79–2.69) | 1.05 (0.77–1.44) | 1.06 (0.79–1.43) |
Sibling history | 1.26 (0.48–3.28) | 2.13 (0.95–4.74) | 0.89 (0.54–1.49) | – | 1.25 (0.73–2.14) |
Family history | 0.97 (0.70–1.35) | 1.62 (0.80–3.29) | 0.86 (0.60–1.21) | – | 0.98 (0.76–1.27) |
