Table 4 Prevalence of gene variants and baseline serum 25-hydroxyvitamin D levels in selected vitamin D-related genes.

From: Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial

 

Prevalence

Median (IQR) ng/mL

P for trend

CYP24A1 rs2209314

T/T

35%

11.4 (8.6, 13.9)

0.62

T/C

51%

10.9 (8.1, 14.3)

 

C/C

15%

9.5 (6.0, 11.9)

 

DBP rs7041

A/A

58%

10.2 (7.6, 14.2)

0.53

A/C

37%

10.9 (8.6, 13.5)

 

C/C

4%

12.3 (11.9, 13.2)

 

DBP rs2282679

T/T

54%

11.5 (9.6, 13.4)

0.93

T/G

36%

8.9 (7.6, 15.1)

 

G/G

10%

10.8 (8.6, 14.5)

 

DBP rs12512631

T/T

56%

11.2 (8.5, 14.9)

0.86

T/C

37%

10.0 (6.9, 12.4)

 

C/C

7%

11.9 (10.3, 12.1)

 

CYP2R1 rs2060793

G/G

42%

10.9 (8.5, 12.6)

0.92

A/G

48%

11.6 (8.3, 15.2)

 

A/A

10%

9.2 (6.0, 11.4)

 

VDR rs11568820

C/C

44%

9.5 (7.2, 11.9)

0.02

T/C

43%

11.9 (8.2, 14.3)

 

T/T

13%

14.3 (10.5, 15.8)

 

DHCR7 rs12785878

G/G

49%

11.0 (8.5, 15.0)

0.42

T/G

36%

10.6 (6.8, 12.7)

 

T/T

15%

11.6 (8.8, 11.9)

 

TMPRSS6 rs855791

A/A

36%

11.3 (9.3, 13.7)

0.66

A/G

49%

10.9 (8.2, 13.7)

 

G/G

15%

10.5 (6.4, 16.2)

 
  1. CYP cytochrome P450, DBP vitamin D binding protein, VDR vitamin D receptor, DHCR7 7-dehydrocholesterol reductase, TMPRSS6 Transmembrane protease serine 6.
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