Figure 3 | Scientific Reports

Figure 3

From: Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years

Figure 3

Associations of bacterial functional pathways and Social Responsiveness Scale-2 (SRS-2) total T-scores. Volcano plots of associations between metagenomically identified functional pathways and SRS-2 total T-scores in full models (adjusting for age at SRS-2, maternal education, marital status, maternal age, paternal age, child sex, maternal self-reported smoking during pregnancy, early exclusive breastfeeding, delivery mode, peripartum antibiotics, and gestational age). Points representing unmapped or unintegrated pathways have been removed for visual clarity (2 points per plot). Dashed blue line indicates p = 0.05, dotted orange line indicates p = 0.001. ARGININE-SYN4-PWY: l-ornithine de novo biosynthesis; ASPASN-PWY: superpathway of l-aspartate and l-asparagine synthesis; OANTINGEN-PWY: O-antigen building blocks biosynthesis (Escherichia coli); PENTOSE-P-PWY: pentose phosphate pathway; PWY0-845: superpathway of pyridoxal 5′-phosphate biosynthesis and salvage.

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