Figure 1 | Scientific Reports

Figure 1

From: Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Figure 1

Structures of nucleosomes employed in the present study. For 145- and 185-nucleosome and oligonucleosomes, one FAM moiety was tagged on the 5′ end of one DNA strand. For the HeLa nucleosome, FAM was introduced to Lys residues of histones by chemical modification, and therefore, one HeLa nucleosome may contain multiple FAM moieties. For the dual labelled 145-nucleosome, one Cy5 fluorophore was tagged on Cys35 of each histone H3. Figures of 145-nucleosome and 185-nucleosome created using data from PDB: 3LZ0 and 1ZBB, respectively.

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