Table 1 Cytotoxic effects of hmxbato on tumor and normal lung cells and their respective IC50 and SCI values.

From: Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

 

IC50 (95% CI)a, µM*

IC50 (95% CI), µM*

Selective Cytotoxicity index (SCI)b

Treatment

A549

BEAS

 

Cisplatin

26.4 (21.1–33.0)

13.38 (10.1–17.7)

0.5

Precursor

21.2 (16.0–28.1)

29.2 (22.3–38.2)

1.4

Free ligand

˂ 200

˂ 200

Not determined

Hmxbato

3.8 (2.3–6.2)

40.3 (22.6–71.7)

10.6

  1. aInhibitory concentration for 50% of cells.
  2. bSCI = IC50 of non-cancerous BEAS-2B-cells/IC50 of cancer A549 cells.
  3. *IC50 values were calculated from concentrations: 200; 100; 50; 25; 12.5; 6.25; 3.12; 1.56; 0.78; 0.39; 0.19 and 0.097 μM.
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