Table 2 Multiple reaction monitoring (MRM) transitions and collision energy of six anti-arrhythmic compounds and internal standards.

From: Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring

Compound

Precursor ion (m/z)

Product ion (m/z)

Collision energy (V)

Metoprolol

268.1

116.1

26

Metoprolol-d7

275.1

123.1

26

Diltiazem

415.2

178.0

33

Amiodarone

646.1

58.1

100

Amiodarone-d4

650.1

58.1

100

Propafenone

342.1

116.1

29

Propafenone-d5

347.1

121.1

29

5OH-propafenone

358.1

116.0

29

5OH-propafenone-d5

363.1

121.1

29

Verapamil

455.3

165.3

37