Figure 1
From: Burn resuscitation strategy influences the gut microbiota-liver axis in swine
Limited-volume resuscitation does not exacerbate measured physiologic derangements compared with MB. (a, b) Representative CT angiogram of the (a) superior mesenteric artery (SMA) and (b) inferior mesenteric artery (IMA). Left panel: green trace indicates selected vessel with red bars indicating the location of cross-sectional measurements. Right panel: cross-section of the selected vessel with blue circle outlining the vessel lumen; red and green lines depict two measurements of vessel lumen diameter. Text indicates measurements of area (blue) and diameter (red and green). Images were acquired with the Vitrea software v6.9.87.1 (https://www.vitalimages.com/vitrea/). (c, d) Quantification of cross-sectional areas of (c) SMA and (d) IMA at baseline (BL) and 48 h post-injury. Bars depict mean and 95% confidence intervals. Images that did not show sufficient contrast could not be measured accurately and were excluded from analysis. (e) Urine output 20 h after burn injury. Experimental replicates are indicated in each respective figure. (f, g) Dimension reduction analysis of 14 clinical biomarkers visualized by PCA biplots with (f) time post-injury or (g) resuscitation strategy supplied as supplementary variables. Each small dot depicts an individual sample, larger dots indicate the centroid of the ellipse. Ellipses depict 95% confidence region. MB (n = 6 pigs), LV-Co (n = 12 pigs), and LV-Cr (n = 12 pigs) *: p < 0.05; **: p < 0.01; ***: p < 0.001, ns: p > 0.05 calculated by ANOVA with Holm family-wise error rate correction at α = 0.05.
