Figure 1
From: Direct visualization of the extracellular binding structure of E-cadherins in liquid
E-cadherin model. (a) Schematic illustration of E-cadherin binding. The extracellular site of E-cadherin is composed of five domains bound in tandem. The binding model is based on crystal structure (PDB ID: 3Q2V28). (b) Crystallography structural model (PDB ID: 3Q2V28) of E-cadherin extracellular domains created with PyMOL. (c) Crystallography structural model (PDB ID: 5JII44) of IgG-Fc domain created with PyMOL. (d) E-cadherin-Fc molecular model created by combining two crystallography structural model (b,c). (e) Schematic illustration of E-cadherin-Fc molecular model. EC5 domain is connected to Fc fragment. Calcium ions are shown as blue spheres.
