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Figure 2

From: Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages

Figure 2

Screening of plasma and serum from Lassa fever survivors for IgG and IgM reactivity to nucleoproteins and glycoprotein from LASV representing lineages II, III and IV. Binding of IgG or IgM in serum or plasma samples from Nigerian (Panel A, n = 140) or Sierra Leonean (Panel B, n = 80) Lassa fever survivors (1:100 dilution) to nucleoprotein (NP) or Prefusion glycoprotein (Pf-GP) was quantified using the Pan-Lassa NP or Pan-Lassa Prefusion-GP ELISA. Data was analyzed using Microsoft Excel (version 16.39, Microsoft, Redmond, WA) and JMP software (version 13.0.0, SAS Institute, Inc., Cary, NC). The figure was compiled using Adobe Illustrator (version 15.1.0, San Jose, CA). Blue dotted lines are linear regression plots of IgG seroreactivity of a mixture of NP representing lineages II–IV versus a mixture of Pf-GP representing lineages II–IV. Orange dotted lines are linear regression plots comparing IgM seroreactivity for the same mixtures.

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