Figure 3 | Scientific Reports

Figure 3

From: Retrospective unbiased plasma lipidomic of progressive multiple sclerosis patients-identifies lipids discriminating those with faster clinical deterioration

Figure 3

PLS-DA discriminates PPMS patients from non-diseased controls based on membrane lipid levels in the plasma. (A) The plots show separation of controls, PPMS-P, and PPMS-NP patients based on the first two components of the partial least square discriminant analysis (PLS-DA). PLS-DA was performed using normalized lipid levels measured in the plasma. Storage, signaling lipids, and lipid metabolism by-products (acyl-carnitines) alone were not able to separate the three groups at the PLS-DA. By contrast, membrane lipids were sufficient to efficiently discriminate patients from controls and PPMS-P from PPMS-NP patients. Control, n = 8; PPMS-NP, n = 10; PPMS-P, n = 9. (B) Graph shows the Variable’s Importance PLS-DA (VIP) scores of lipids that more prominently contributed to the PLS-DA model (VIP > 2). Red asterisk indicates SM(d18:1/14:0), the lipid with the highest VIP score and thus one of the lipids that most contributed to the PLS-DA model.

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