Table 1 Clinical and treatment features with associated OS.

Variables	N	Univariate		Multivariate
Variables	N	Median OS (month)	P value	Hazard ratio	P value
Age at diagnosis
> 35 years	42	12	0.449
18–35 years	57	17
≤ 18 years	62	18
Sex
Female	89	21	0.009	0.581	0.088
Male	72	13
Tumor site
Visceral	90	15	0.138
Non-visceral	71	18
Surgery
Yes	136	18	< 0.001	0.362	0.005
No	25	10
Chemotherapy
Yes	135	17	0.001	2.547	0.225
No	26	13.5
Radiotherapy
Yes	67	19	0.235
No	94	14
Tumor diameter
≤ 5 cm	34	17	0.049	1.393	0.029
> 5 cm, ≤ 10 cm	58	22.5
> 10 cm	45	14
Unknown	24	14.5
Lymph node status
No metastasis	55	26	0.024	1.374	0.122
Metastasis	17	15
Unknown	89	14
Pretreatment LDH level
Elevated	15	12	0.062
Normal	28	28
Unknown	118	15.5
Resection
R0	62	19.5	< 0.001	1.045	0.678
R1	6	12.5
R2	18	6.5
Extent of resection unknown	50	19
Biopsy only	25	10
Tumor stage
II	15	26	0.107
III	33	22
IV	43	12
Stage unknown	70	15
Cycles of chemotherapy
> 10	32	33	< 0.001	0.370	< 0.001
4–10	77	16
< 4	23	12
No chemotherapy	26	13.5
Cycles unknown	3	19
Dose of radiotherapy
> 50 Gy	24	28.5	0.376
> 30 Gy, ≤ 50 Gy	33	18
≤ 30 Gy	10	15.5
No radiotherapy	94	14
Chemotherapy regimen
VDC/IE	87	18	0.017	1.082	0.814
Other regimens	42	16.5
Regimen unknown	6	9.5
No chemotherapy	26	13.5

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