Figure 5

Electron micrographs of XFS fibrils from the surface of lens capsule XFS-M3. (a) Electron micrographs of negatively stained (using 2% UA), isolated XFS deposits from a lens capsule of an 83-year-old male patient (sample M3) being in moderate stages of XFS at the time of surgery. Arrows in (a) indicate helical twist regions (scale bars = 50 nm). (b) First panel: a representative 2D class average of the 10 nm filaments displaying two protofilaments. One and two protofilaments are designated by white arrowheads and arrows, respectively. Second panel: a schematic illustration of the 2D class average image (scale bar = 10 nm). (c) First panel: 2D class average of 20 nm fibrils displaying two distinct physical entities. One and two protofilaments are designated by white arrowheads and arrows, respectively. Second panel: a schematic illustration of the 2D class average image (scale bar = 10 nm).