Figure 7
IL-1R−/− mice are protected from T. gondii-induced cachexia and cachexia-associated liver atrophy. Total body weight of mice pre-infection and 9 wpi. N = 20–33 mice per group, pooled between 7 independent experiments. ξP < 0.0001 by paired Student’s t test. ****P < 0.0001 by unpaired Student’s t test. (b) Quantity of T. gondii DNA relative to host beta-actin in the brain at 9 wpi. N = 3–11 mice per group, representative of 3 independent experiments. (c–e) Tissue weights of quad (c), liver (d), and vWAT (e) at 9 or 18 wpi. 9 wpi data is representative of at least 4 independent experiments, 18 wpi data is pooled between two independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001, ****P < 0.0001 by unpaired Student’s t test with Holm–Sidak correction for multiple comparisons.
