Table 2 31 potential anti-breast cancer target genes of active components.

From: Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer

UniProt ID

Protein name

Gene name

P04626

Receptor tyrosine-protein kinase erbB-2

ERBB2

Q9SAD4

Ethylene-responsive transcription factor ESR1

ESR1

P31749

RAC-alpha serine/threonine-protein kinase

AKT1

P15692

Vascular endothelial growth factor A

VEGFA

P35222

Catenin beta-1

CTNNB1

P01106

Myc proto-oncogene protein

MYC

P10275

Androgen receptor

AR

P01375

Tumor necrosis factor

TNF

P00533

Epidermal growth factor receptor

EGFR

Q14790

Caspase-8

CASP8

Q92731

Estrogen receptor beta

ESR2

P42345

Serine/threonine-protein kinase mTOR

MTOR

P10415

Apoptosis regulator Bcl-2

BCL2

P12931

Proto-oncogene tyrosine-protein kinase Src

SRC

P05093

Steroid 17-alpha-hydroxylase/17,20 lyase

CYP17A1

P11388

DNA topoisomerase 2-alpha

TOP2A

P01133

Pro-epidermal growth factor

EGF

P03956

Interstitial collagenase

MMP1

P16083

Ribosyldihydronicotinamide dehydrogenase [quinone]

NQO2

P42574

Caspase-3

CASP3

P35354

Prostaglandin G/H synthase 2

PTGS2

P14780

Matrix metalloproteinase-9

MMP9

P08253

72 kDa type IV collagenase

MMP2

Q16678

Cytochrome P450 1B1

CYP1B1

Q9UNQ0

ATP-binding cassette sub-family G member 2

ABCG2

P08183

Multidrug resistance protein 1

ABCB1

P05412

Transcription factor AP-1

JUN

P35228

Nitric oxide synthase

NOS2

P37231

Peroxisome proliferator-activated receptor gamma

PPARG

P35869

Aryl hydrocarbon receptor

AHR

P09874

Poly [ADP-ribose] polymerase 1

PARP1