Table 2 Half-maximum effective concentration (EC50) values of test articles on changes in intracellular Ca2+ levels in human or dog MRGPRX2-expressing cells.

From: Identification of the dog orthologue of human MAS-related G protein coupled receptor X2 (MRGPRX2) essential for drug-induced pseudo-allergic reactions

Test article

EC50 (μg/mL) ± SD

Human MRGPRX2

Dog MRGPRX2

Compound 48/80

3.0 ± 0.5

1.1 ± 0.4

CPFX

93.5 ± 10.3

14.5 ± 1.8

GFLX

198.5 ± 19.7

78.7 ± 10.9

LVFX

384.7 ± 101.3

58.9 ± 19.9

  1. Data represent the mean ± SD of three independent experiments.
  2. CPFX ciprofloxacin, GFLX gatifloxacin, LVFX levofloxacin.
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