Table 1 One-way analysis of variance and trend analysis showing volatile metabolites that have concentration–response relationships with particle exposure.
From: A novel lung alveolar cell model for exploring volatile biomarkers of particle-induced lung injury
Compound | CAS no. | Non-exposed control | 200 μg/mL | 500 μg/mL | p for trend |
|---|---|---|---|---|---|
Mean (SE) | Mean (SE) | Mean (SE) | |||
Principal component 1 | |||||
1,2,4-Oxadiazole, 5-(4-nitrophenyl)-3-phenyl- | 28825-12-9 | 0.80 (0.41) | 0.87 (0.10) | 1.18 (0.22) | 0.40 |
2,6-Dimethyl-6-trifluoroacetoxyoctane | 61986-67-2 | 7.51 (1.86) | 8.55 (2.06) | 10.58 (1.61) | 0.32 |
Principal component 2 | |||||
3-Buten-1-amine, N,N-dimethyl- | 55831-89-5 | 1.27 (0.72) | 2.45 (0.65) | 17.69 (9.13) | 0.049* |
2-Propanol, 2-methyl- | 75-65-0 | 1.87 (0.81) | 2.56 (0.62) | 12.31 (6.69) | 0.08 |
Glycolaldehyde dimethyl acetal | 30934-97-5 | 0.43 (0.25) | 8.25 (2.53) | 9.55 (3.07) | 0.02* |
Propanoic acid, 2-oxo-, ethyl ester | 617-35-6 | 0.23 (0.09) | 0.25 (0.06) | 0.73 (0.34) | 0.11 |
Octane | 111-65-9 | 0.96 (0.26) | 1.54 (0.35) | 5.26 (2.50) | 0.06 |
Octane, 3,3-dimethyl- | 4110-44-5 | 1.43 (0.79) | 1.66 (0.30) | 10.05 (4.52) | 0.04* |
Heptane, 2,3-dimethyl- | 3074-71-3 | 0.19 (0.09) | 0.47 (0.04) | 2.58 (1.02) | 0.01* |
Ethanedioic acid, bis(trimethylsilyl) ester | 18294-04-7 | 2.93 (1.06) | 6.56 (1.91) | 9.81 (2.59) | 0.03* |
