Figure 4

Characterization of the transcriptome of conjunctival melanoma (CM). (A) Volcano plot showing the up- and downregulated genes (red and green, respectively) in CM in comparison to normal conjunctiva. Genes not differentially expressed are shown in grey. The top ten upregulated as well as the top five downregulated genes in melanoma are labeled. (B) Gene ontology (GO) analysis of the differentially expressed genes in conjunctival melanoma. The top ten biological processes, which the DEG were involved in, are shown in the dot plot. “Inhibition of apoptosis” summarizes the two GO terms “negative regulation of apoptotic process” and “negative regulation of programmed cell death”, which overlapped with all 106 associated DEG. The size of the dots represents the number of associated genes (count). The adjusted p value of each GO term is shown by color. The gene ratio describes the ratio of the count to the number of all DEG. (C) Box plots illustrating normalized reads of the top five upregulated factors of three disease-relevant GO terms arranged by log2 fold change.