Figure 3
Top: In vivo coronal SPEN images focusing on the changes in ADCs experienced by fetal brains (exemplified by red arrows) in wildtype vs eNOS−/− mice, for E14.5 and E17.5 days of pregnancy. Shown for each animal are b = 0 and 750 s/mm2 (nominal values) DWIs, as well as the derived isotropic ADC maps. FOVs and slice thicknesses for all the slices was 30 × 30 × 1 mm3; additional parameters: TR/TE 2000/42 ms, 5 interleaves, 4 averages. Bottom: ADC distributions that could be extracted from the images shown on top, for the different animals and ages. Error bars in the histograms (in black) reflect the distribution in the values as could be measured for the whole cadre of fetuses in all the animals.
