Figure 7
Images and perfusion maps extracted for placentas in wildtype, eNOS−/−, IL10−/− and l-NAME-treated mice, calculated using the steepest slope model (see Materials and Methods). The upper row shows T2-weighted anatomical RARE images indicating placentas with white arrows. The middle row shows the FLASH images and perfusion maps extracted for the indicated placentas. The lower row shows mean perfusion coefficients for whole individual placentas, as well as for the segmented labyrinth (fetal side) and decidual compartments. Error bars indicate the range observed in these values over the mice cohorts. Measurements included n = 3 wildtype mice (total number of fetuses = 12), n = 3 eNOS−/− mice (number of fetuses = 15), n = 3 IL10−/− mice (number of fetuses = 13), and two l-NAME-injected mice (number of fetuses = 7). Data were recorded at age E14.5 for the wildtype and knockout mice, and E16.5 for the l-NAME treated one.
