Figure 8 | Scientific Reports

Figure 8

From: A structure-based computational workflow to predict liability and binding modes of small molecules to hERG

Figure 8

Lidocaine low-energy binding mode (a) Structure of the lidocaine-bound channel side view (top) and 90° rotated extracellular view (bottom). (b) A zoomed-in view of lidocaine-bound to the central cavity. (c) A 2D representation of lidocaine interactions with the residues in the central cavity. (Numbers show the distance between the two groups in angstrom). SF selectivity filter, CC central cavity.

Back to article page