Figure 6
From: PRMT5-mediated methylation of YBX1 regulates NF-κB activity in colorectal cancer
Ingenious pathway analysis (IPA) of genes regulated by R205 methylation and their associated networks and functions. (A) Ingenious pathway analysis (IPA), showing list of upstream regulators (IL-1β, TNF and NF-κ) as well as top network cellular functions associated with R205 methylation such as cell death, survival, proliferation and movement (left and middle panel, respectively). The right panel shows that the genes regulated by R205 methylation are associated with networks linked to diseases such as cancer and inflammatory-related disorders. (B) Representative networks reveal NF-κB-related proteins as critical nodes in these networks.
