Figure 4 | Scientific Reports

Figure 4

From: Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis

Figure 4

Effects of ETAR inhibition on the transcriptome of COLO- 357 cells. (a) Heatmap of hierarchical clustering shows the transcriptome profile of COLO-357 cells in the absence or presence of ambrisentan and/or Par2 antagonist. The transcriptional levels are represented in a log2 scale. (b) Gene Set Variation Analysis (GSVA) displays enriched (downregulated in blue and upregulated in orange) pathways in the absence or presence of ambrisentan and/or Par2 agonist.

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