Figure 2
Influence of micropillar geometry on animal locomotion and lifespan. (a) Crawling amplitude, wavelength, and speed of day 4 animals as pillar spacing was changed within the three devices (n = 10). Pillar diameter and edge-edge gap for Devices I, II and III are: 40 μm, 60 μm; 50 μm, 80 μm; 60 μm, 100 μm. Older adults are most constrained in Device I and are not constrained in Device III. (b) Wild type C. elegans lifespan as a function of confinement (n = 56 for Device-I, n = 71 for Device-II and n = 60 for Device-III). p value for lifespan curve between Device-I and II is 0.99 and p-value for lifespan curve between Device-I and III is 0.026 (Log-rank (Mantel-Cox) test, N = 2 repeat trials. Data is shown for one trial.
