Table 2 Outcomes for residual deep sites and healed sites depending on the presence of A. actinomycetemcomitans, P. gingivalis and T. denticola. Mean number (N) of residual deep sites (PD ≥ 6 mm) and of sites achieving pocket closure (PD < 4 mm) at 6 and 12 m depending on the presence/absence at baseline, at 6 or 12 months of the periodontal pathogens A. actinomycetemcomitans, P. gingivalis and T. denticola (Group A: Placebo, Group B: 3 days AMX + MET, Group C: 7 days AMX + MET; Aa: A. actinomycetemcomitans; Pg: P. gingivalis; m: months; Base: baseline; N: number of patients). Baseline, 6 m and 12 m data for the number of sites ≥ 6 mm of all patients had been previously published in Cosgarea et al. 2017.
Variables | Group A (N = 26) Mean ± SD | Group B (N = 24) Mean ± SD | Group C (N = 25) Mean ± SD | p (A–B) | p (A–C) | p (B–C) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PD ≥ 6 mm | PD ≤ 3 mm | PD ≥ 6 mm | PD ≤ 3 mm | PD ≥ 6 mm | PD ≤ 3 mm | PD ≥ 6 mm | PD ≤ 3 mm | PD ≥ 6 mm | PD ≤ 3 mm | PD ≥ 6 mm | PD ≤ 3 mm | |
All patients | N = 26 | N = 26 | N = 24 | N = 24 | N = 25 | N = 25 | ||||||
Base | 25.50 ± 17.36 | – | 29.37 ± 14.65 | – | 35.92 ± 17.58 | – | 1.000 | – | 0.098 | – | 0.592 | – |
6 m | 8.92 ± 6.63 | 38.70 ± 19.10 | 2.08 ± 3.43 | 52.60 ± 19.60 | 5.00 ± 5.11 | 51.90 ± 19.00 | < 0.001 | 0.039 | 0.001 | 0.051 | 0.303 | 1.000 |
12 m | 5.19 ± 3.71 | 39.00 ± 17.30 | 1.66 ± 2.26 | 52.30 ± 19.20 | 4.52 ± 5.49 | 51.50 ± 19.90 | 0.003 | 0.044 | 0.917 | 0.059 | 0.068 | 1.000 |
Aa negative (Base) | N = 12 | N = 12 | N = 19 | N = 19 | N = 16 | N = 16 | ||||||
6 m | 6.83 ± 5.54 | 39.17 ± 20.92 | 2.53 ± 3.75 | 53.32 ± 18.45 | 4.94 ± 5.43 | 52.19 ± 19.17 | 0.005 | 0.160 | 0.086 | 0.254 | 0.924 | 1.000 |
12 m | 4.92 ± 3.55 | 39.25 ± 17.75 | 1.47 ± 1.98 | 54.11 ± 18.3 | 4.06 ± 5.42 | 53.25 ± 21.12 | 0.019 | 0.124 | 0.664 | 0.187 | 0.302 | 1.000 |
Aa positive (Base) | N = 14 | N = 14 | N = 5 | N = 5 | N = 9 | N = 9 | ||||||
6 m | 9.57 ± 6.65 | 38.4 ± 18.3 | 4.00 ± 5.48 | 50.0 ± 26.11 | 4.33 ± 3.12 | 51.4 ± 19.9 | 0.008 | 0.840 | 0.047 | 0.428 | 0.886 | 1.000 |
12 m | 4.71 ± 3.63 | 38.71 ± 1.758 | 2.00 ± 2.92 | 45.20 ± 23.18 | 4.56 ± 4.39 | 48.44 ± 18.2 | 0.603 | 1.000 | 1.000 | 0.709 | 0.924 | 1.000 |
Aa negative | ||||||||||||
At 6 m | 7.94 ± 5.43 | 41.11 ± 21.44 | 2.31 ± 3.83 | 54 ± 10 ± 20.26 | 4.65 ± 5.34 | 52.51 ± 19.55 | 0.001 | 0.200 | 0.037 | 0.345 | 0.933 | 1.000 |
At 12 m | 4.83 ± 3.47 | 41.30 ± 17.63 | 1.64 ± 2.22 | 51.51 ± 19.35 | 3.78 ± 5.07 | 56.22 ± 19.51 | 0.015 | 0283 | 0.487 | 0.065 | 0.560 | 1.000 |
Aa positive | ||||||||||||
At 6 m | 8.90 ± 7.42 | 35.00 ± 15.09 | 1.20 ± 8.37 | 47.21 ± 18.17 | 4.88 ± 3.09 | 50.81 ± 19.07 | 0.005 | 0.630 | 0.030 | 0.204 | 1.000 | 1.000 |
At 12 m | 4.75 ± 3.88 | 33.81 ± 16.41 | 1.00 ± 1.41 | 60.51 ± 21.92 | 5.43 ± 4.93 | 39.61 ± 16.39 | 0.355 | 0.283 | 1.000 | 0.065 | 0.303 | 1.000 |
Pg negative (Base) | N = 1 | N = 1 | N = 4 | N = 4 | N = 3 | N = 3 | ||||||
6 m | 7.00 | 12.00 | 0 ± 0 | 59.0 ± 20.69 | 3.33 ± 3.51 | 41.67 ± 20.31 | 0.196 | 0.288 | 0.840 | 0.799 | 0.549 | 0.958 |
12 m | 6.00 | 18.00 | 0 ± 0 | 55.0 ± 18.89 | 4.67 ± 7.23 | 44.00 ± 30.51 | 1.000 | 0.690 | 1.000 | 1.000 | 0.774 | 1.000 |
Pg positive (Base) | N = 25 | N = 25 | N = 20 | N = 20 | N = 22 | N = 22 | ||||||
6 m | 8.36 ± 6.32 | 39.80 ± 18.74 | 2.50 ± 3.63 | 51.35 ± 19.75 | 4.91 ± 4.84 | 53.32 ± 18.89 | < 0.001 | 0.144 | 0.003 | 0.055 | 0.748 | 1.000 |
12 m | 4.76 ± 3.59 | 39.80 ± 17.11 | 1.90 ± 2.22 | 51.70 ± 19.71 | 4.18 ± 4.84 | 52.55 ± 18.79 | 0.013 | 0.106 | 0.700 | 0.064 | 0.272 | 1.000 |
Pg negative | ||||||||||||
At 6 m | 9.67 ± 6.91 | 49.71 ± 19.87 | 2.20 ± 3.49 | 54.40 ± 19.15 | 4.71 ± 4.95 | 53.21 ± 19.89 | 0.003 | x | 0.028 | x | 0.771 | |
At 12 m | 3.50 ± 3.59 | 38.51 ± 14.77 | 1.00 ± 1.69 | 53.90 ± 19.75 | 3.89 ± 4.83 | 53.80 ± 21.59 | 0.376 | 0.255 | 1.000 | 0.226 | 0.186 | 1.000 |
Pg positive | ||||||||||||
At 6 m | 7.59 ± 5.88 | 32.90 ± 16.51 | 1.89 ± 3.55 | 49.70 ± 21.31 | 4.75 ± 3.30 | 45.01 ± 13.39 | 0.001 | 1.000 | 0.153 | 1.000 | 1.000 | 1.000 |
At 12 m | 5.39 ± 3.43 | 39.21 ± 18.72 | 2.56 ± 2.55 | 49.01 ± 19.12 | 5.33 ± 5.78 | 44.30 ± 11.60 | 0.095 | 0.492 | 1.000 | 1.000 | 0.556 | 1.000 |
Td negative (Base) | N = 3 | N = 3 | N = 0 | N = 0 | N = 1 | N = 1 | ||||||
6 m | 9.00 ± 8.18 | 36.01 ± 20.88 | – | – | 0.00 ± 0.00 | 32.02 ± 0.00 | – | – | 0.527 | 0.883 | – | – |
12 m | 5.33 ± 2.01 | 38.71 ± 24.68 | – | – | 0.00 ± 0.00 | 35.00 ± 0.00 | – | – | 0.412 | 0.909 | – | – |
Td positive (Base) | N = 23 | N = 23 | N = 24 | N = 24 | N = 24 | N = 24 | ||||||
6 m | 8.22 ± 6.13 | 39.10 ± 19.39 | 2.08 ± 3.44 | 52.60 ± 19.66 | 4.92 ± 4.66 | 52.81 ± 18.96 | < 0.001 | 0.058 | 0.001 | 0.054 | 0.499 | 1.000 |
12 m | 4.74 ± 5.01 | 39.01 ± 16.88 | 1.58 ± 2.15 | 52.31 ± 19.21 | 4.42 ± 5.01 | 52.20 ± 19.98 | 0.008 | 0.055 | 1.000 | 0.056 | 0.092 | 1.000 |
Td negative | ||||||||||||
At 6 m | 7.60 ± 7.04 | 43.20 ± 18.92 | 2.07 ± 3.55 | 55.55 ± 21.71 | 5.20 ± 4.90 | 49.41 ± 19.26 | 0.017 | 0.448 | 0.262 | 1.000 | 0.421 | 1.000 |
At 12 m | 3.43 ± 3.18 | 44.03 ± 18.88 | 1.00 ± 1.69 | 56.61 ± 19.04 | 2.94 ± 4.25 | 55.30 ± 21.88 | 0.080 | 0.305 | 1.000 | 0.392 | 0.524 | 1.000 |
Td positive | ||||||||||||
At 6 m | 8.75 ± 5.81 | 35.91 ± 19.36 | 2.09 ± 3.48 | 49.22 ± 17.31 | 2.80 ± 3.27 | 62.00 ± 15.76 | < 0.001 | 0.220 | 0.004 | 0.027 | 1.000 | 0.606 |
At 12 m | 6.42 ± 3.32 | 33.10 ± 13.75 | 2.56 ± 2.55 | 45.21 ± 18.38 | 6.56 ± 5.59 | 44.81 ± 14.36 | 0.050 | 0.257 | 1.000 | 0.292 | 0.225 | 1.000 |
