Table 4 Qualitative microbial analysis. Detection frequency of periodontopathogenic microorganisms (Group A: Placebo, Group B: 3 days AMX + MET, Group C: 7 days AMX + MET; ^sstatistical significant p values 0.001 < p < 0.05; ^hshighly statistically significant values p ≤ 0.001; Base: baseline, m: months, Δ: change).

From: Microbiological and host-derived biomarker evaluation following non-surgical periodontal therapy with short-term administration of systemic antimicrobials: secondary outcomes of an RCT

Variables	Group A (n = 26) n/%	Group B (n = 24) n/%	Group C (n = 25) n/%	p (A–B)	p (A–C)	p (B–C)
*A. actinomycetemcomitans*
Base	15/50	7/23.3	11/35.5	0.032^s	0.259	0.305
3 m	15/50	3/10	10/32.3	0.001^s	0.165	0.034s
6 m	12/40	10/33.3	10/32.3	0.599	0.537	0.930
12 m	14/46.7	9/30	15/48.4	0.190	0.895	0.146
*P. gingivalis*
Base	29/96.7	26/86.7	28/90.3	0.168	0.325	0.661
3 m	19/63.3^s	12/40^hs	7/22.6^hs	0.073	0.001^s	0.147
6 m	20/66.7^s	13/43.3^hs	7/22.6^hs	0.071	< 0.000^hs	0.087
12 m	25/83.3	16/53.3^s	14/54.2^hs	0.012^s	0.001^hs	0.531
*T. denticola*
Base	27/90	30/100	30/96.8	0.078	0.293	0.329
3 m	17/56.7^s	12/40^hs	12/38.7^hs	0.203	0.166	0.920
6 m	20/66.7^s	15/50^hs	10/32.3^hs	0.197	0.007^s	0.164
12 m	19/63.3^s	15/50^hs	16/51.6^hs	0.305	0.363	0.902
*T. forsythia*
Base	23/76.7	21/70	21/67.7	0.567	0.445	0.852
3 m	10/33.3^s	3/10^hs	7/22.6^hs	0.028^s	0.357	0.191
6 m	15/50	10/33.3^hs	6/19.4^s	0.197	0.011^s	0.221
12 m	12/40^s	16/53.3	12/38.7^s	0.309	0.920	0.259
*F. nucleatum*
Base	29/96.7	30/100	29/93.5	0.321	0.581	0.162
3 m	27/90	22/73.3^s	26/83.9	0.098	0.487	0.323
6 m	28/93.3	23/76.7^s	21/67.7^s	0.073	0.011^s	0.445
12 m	29/96.7	27/90	27/87.1	0.310	0.179	0.727
*P. micra*
Base	27/90	29/96.7^s	26/83.9^s	0.309	0.487	0.096
3 m	24/80	17/56.7^s	14/45.2^hs	0.053	0.004^s	0.377
6 m	26/86.7	19/63.3^s	13/41.9	0.037^s	< 0.0001^hs	0.097
12 m	22/73.3	23/76.7	21/67.7	0.770	0.639	0.445
*C. rectus*
Base	27/90	25/83.3	28/90.3	0.456	0.967	0.427
3 m	24/80	16/53.3^s	17/54.8^hs	0.029^s	0.037^s	0.908
6 m	25/83.3	23/76.7	18/58.1^s	0.527	0.031^s	0.126
12 m	26/86.7	22/73.3	24/77.4	0.203	0.356	0.717
*F. allocis*
Base	27/90	28/93.3	25/80.6	0.647	0.311	0.147
3 m	23/76.7	13/43.3^hs	15/48.4^s	0.008^s	0.022^s	0.698
6 m	23/76.7	19/63.3^s	15/48.4^s	0.267	0.023^s	0.247
12 m	22/73.3	20/66.7^s	15/48.4^s	0.581	0.047^s	0.154

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