Table 5 Quantitative immunological analysis. Mean levels and group comparisons (one way ANOVA, Bonferroni correction for inter- and intra-group comparisons between different timepoints) of immunological (IL-1β, IL-10, TNF α, MMP8) parameters (mean ± SD) (Group A: Placebo, Group B: 3 days AMX + MET, Group C: 7 days AMX + MET; sstatistical significant p values; IL: Interleukin; TNF: tumor necrosis factor; MMP: matrix metallo protease; Base: baseline, m: months, Δ: change).

From: Microbiological and host-derived biomarker evaluation following non-surgical periodontal therapy with short-term administration of systemic antimicrobials: secondary outcomes of an RCT

Variables

Group A

N = 26

Group B

N = 24

Group C

N = 25

Group comparisons

p (A–B)

p (A–C)

p (B–C)

IL 1β

Base

18.00 ± 18.39

26.57 ± 20.46

34.54 ± 24.48

0.275

0.009s

0.322

3 m

9.21 ± 11.71

10.66 ± 12.83hs

8.00 ± 12.04hs

0.892

0.926

1.000

6 m

11.25 ± 15.96

10.00 ± 10.67s

9.32 ± 15.55hs

0.947

0.868

1.000

12 m

18.36 ± 20.62

18.01 ± 20.76

14.31 ± 14.47s

0.998

0.728

1.000

Δ base-3 m

7.06 ± 21.29

15.75 ± 18.10s

28.65 ± 26.30s

0.298

0.001hs

0.091

Δ base-6 m

7.98 ± 26.23

12.09 ± 19.35s

27.21 ± 29.25s

0.833

0.016s

0.107

Δ base-12 m

− 2.64 ± 25.54

9.03 ± 28.12

21.91 ± 29.59s

0.321

0.007s

0.320

Δ 3 m–6 m

− 1.80 ± 19.26

0.86 ± 12.60

− 2.22 ± 12.27

0.802

0.994

1.000

Δ 6 m–12 m

− 7.29 ± 27.48

− 10.10 ± 23.82s

− 3.23 ± 19.92s

0.917

0.833

0.981

IL-10

Base

0.65 ± 1.65

0.29 ± 0.77

0.33 ± 0.96

0.476

0.546

1.000

3 months

2.30 ± 4.39

0.66 ± 1.32

0.80 ± 2.39

0.092

0.145

1.000

6 months

2.29 ± 3.99

0.93 ± 2.75

0.54 ± 2.24

0.243

0.089

1.000

12 m

0.93 ± 3.85

1.06 ± 3.48

2.22 ± 5.06

0.993

0.528

0.989

Δ base-3 m

− 1.62 ± 4.80

− 0.39 ± 1.51

− 0.52 ± 2.01

0.297

0.364

1.000

Δ base-6 m

− 1.61 ± 4.40

− 0.68 ± 2.97

− 0.19 ± 2.26

0.576

0.248

1.000

Δ base-12 m

− 0.11 ± 4.19

− 0.81 ± 3.73

− 1.82 ± 5.34

0.852

0.377

1.000

Δ 3 m–6 m

0.09 ± 6.56

− 0.21 ± 2.89

0.25 ± 2.05

0.964

0.990

1.000

Δ 6 m–12 m

1.89 ± 6.40

0.48 ± 3.75

− 1.25 ± 5.65

0.643

0.121

0.797

IL-8

Base

15.84 ± 18.73

23.48 ± 24.74

30.36 ± 37.26

0.553

0.115

1.000

3 m

16.67 ± 23.13

15.98 ± 17.89

9.36 ± 13.72s

0.989

0.308

0.343

6 m

27.09 ± 33.23s

15.00 ± 15.07

12.32 ± 14.40s

0.130

0.043s

1.000

12 m

21.34 ± 23.71

18.18 ± 24.22

22.12 ± 24.39

0.891

0.993

1.000

Δ base-3 m

− 0.47 ± 29.13

6.94 ± 21.67

21.89 ± 38.27s

0.353

0.218

0.199

Δ base-6 m

− 13.55 ± 37.03

4.64 ± 26.09

19.00 ± 40.43s

0.998

0.177

0.424

Δ base-12 m

− 7.67 ± 28.96

0.46 ± 27.50

8.78 ± 40.19

0.096

0.007s

1.000

Δ 3 m–6 m

11.92 ± 38.47

0.34 ± 19.13

− 1.97 ± 19.97

0.213

0.951

1.000

Δ 6 m–12 m

5.57 ± 34.78

− 2.35 ± 25.72

− 11.11 ± 19.96

0.308

0.564

0.808

MMP 8

Base

2471.56 ± 1815.96

3335.60 ± 2596 ± 56

4000.64 ± 2320.63

0.313

0.027s

0.494

3 m

1153.20 ± 1313.64s

3096.09 ± 4814.24

1475.57 ± 1017.55hs

0.038s

0.913

0.126

6 m

1758.83 ± 1489.02

2437.04 ± 2862.80

1886.99 ± 1225.48hs

0.415

0.967

0.904

12 m

2167.45 ± 1299.59

2013.63 ± 1281.73

1774.55 ± 1260.12hs

0.907

0.527

1.000

Δ base-3 m

1299.79 ± 24.03.82s

140.72 ± 4063.02

2719.78 ± 2844.77s

0.353

0.218

0.009s

Δ base-6 m

654.65 ± 2663.64

704.47 ± 4608.73

2234.41 ± 2454.42s

0.998

0.177

0.285

Δ base-12 m

− 110.74 ± 1754.95

1367.94 ± 2912.39s

2039.03 ± 2480.36s

0.096

0.007s

0.999

Δ 3 m–6 m

− 669.59 ± 1867.51s

737.49 ± 4668.56

− 422.41 ± 1586.20

0.213

0.951

0.497

Δ 6 m–12 m

− 471.55 ± 1933.76

473.00 ± 3078.88

182.99 ± 866.14

0.308

0.564

1.000

Back to article page