Figure 6
Comparison of drift time profiles representing conformational ensembles for the 8+ charge state of unbound α syn (control) and with four metal ions bound, arranged per oxidation state. (a) Singly charged alkali metal ions (M+) shift the distribution towards the most extended conformation “A”. (b) Doubly charged metal ions (M++) have the opposite effect with compact states (“C” and “D”) dominating, but the drift time profiles look different in each case. (c) La3+ binding (M+++) leads to compaction similar to doubly charged ions, but again the conformational pattern is different. Different conformations are labelled “A” (most extended) to “D” (most compact).
