Table 1 Screening of serum chemokines and cytokines as complementary biomarkers for early diagnosis and prognosis of congenital toxoplasmosis.

From: Putative biomarkers for early diagnosis and prognosis of congenital ocular toxoplasmosis

Diagnosis

Early prognosis

Biomarkersa (pg/mL)

CTL × TOXO

Biomarkersb (pg/mL)

TOXO (NL × L)

Biomarkersc (pg/mL)

TOXO (AL × CL)

AUC

Se (%)

Sp (%)

AUC

Se (%)

Sp (%)

AUC

Se (%)

Sp (%)

CXCL9

0.9

84

81

IL-5

0.6

92

28

IL-12p70

0.6

91

30

CXCL10

0.8

82

69

TNF

0.6

78

50

IL-6

0.6

87

30

CCL5

0.6

83

42

CXCL8

0.6

68

50

CCL2

0.6

84

37

CXCL8

0.6

68

50

IL-6

0.6

62

61

CCL5

0.6

78

37

IFN-γ

0.6

58

65

CCL2

0.6

61

72

IL-17A

0.6

72

46

IL-12p70

0.6

56

61

IFN-γ

0.6

55

72

IL-4

0.6

63

52

IL-1β

0.6

52

65

CCL5

0.6

40

78

IL-1β

0.5

96

15

TNF

0.6

31

83

IL-17A

0.5

83

33

IL-10

0.5

94

21

IL-10

0.5

91

22

IL-1β

0.5

81

39

CXCL8

0.5

93

17

CCL2

0.5

91

23

IL-4

0.5

71

50

IL-5

0.5

93

27

IL-17A

0.5

91

22

CXCL9

0.5

68

50

IFN-γ

0.5

59

52

IL-4

0.5

85

30

IL-12p70

0.5

51

61

TNF

0.5

48

70

IL-5

0.5

51

70

IL-10

0.5

46

72

CXCL9

0.5

40

74

IL-6

0.5

42

74

CXCL10

0.5

13

100

CXCL10

0.5

31

86

  1. CTL = Uninfected infant controls (n = 26); TOXO = Infants with congenital toxoplasmosis (n = 108); NL = no retinochoroidal lesion (n = 18); L = retinochoroidal lesion (n = 90); AL = active retinochoroidal lesion (n = 35); CL = cicatricial retinochoroidal lesion (n = 55); AUC = Area under the ROC curve; Se = Sensitivity; Sp = Specificity. Bold values and letters correspond to biomarkers with high accuracy (>0.8).
  2. aCut-off: CXCL9 = 6754; CXCL10 = 12,050; CCL5 = 937; CXCL8 = 3.3; IFN-γ = 1,565; IL-12p70 = 72; IL-1β = 197; TNF = 64; IL-10 = 98; CCL2 = 230; IL-17A = 795; IL-4 = 704; IL-5 = 451 and IL-6 = 1,861.
  3. bCut-off: IL-5 = detectable levels; TNF = 346; CXCL8 = 3.3; IL-6 = 986; CCL2 = 59; IFN-γ = 2,031; CCL5 = 1,295; IL-17A = 335; IL-1β = 83; IL-4 = 342; CXCL9 = 10,135; IL-12p70 = 275; IL-10 = 887 and CXCL10 = 8523.
  4. cCut-off: IL-12p70 = 4617; IL-6 = 3,460; CCL2 = 141; CCL5 = 2,215; IL-17A = detectable levels; IL-4 = 249; IL-1β = 1,065; IL-10 = 138; CXCL8 = 1.2; IL-5 = 2,914; IFN-γ = 1,414; TNF = 91; CXCL = 15,256 and CXCL10 = 24,694.
Back to article page