Figure 4
From: Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency
Optic nerve axon density declines in Vglut2-Cre;ndufs4loxP/loxP mice by P60. (A) Representative light microscopy images of ndufs4loxP/loxP, Vglut2-Cre;ndufs4+/+, and Vglut2-Cre;ndufs4loxP/loxP optic nerve cross-sections stained with methylene blue at P30 and P90. Scale bar, 20 μm. (B) Bar graphs comparing axon density between the indicated genotypes at the proximal portion of the optic nerve. Bars depict mean ± SEM; n = number of optic nerves per genotype; ** p < 0.001; ***, p < 0.0001; ns, not significant. Image acquisition and axon quantification performed with AxioVision SE64 Rel. 4.9.1 software.
