Figure 8 | Scientific Reports

Figure 8

From: Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor

Figure 8

Maternal high-fat diet (HFD)-induced changes in serum metabolites reflective of alterations in gut microbiome in young male and female offspring: the effect of acute ozone exposure. Box plots showing ozone-induced changes in serum 4-ethylphenyl sulfate (A), catechol sulfate (B), hippurate (C), 3-(4-hydroxyphenyl) lactate (D), phenol sulfate (E), and phenol glucuronide (F). *Significant effect of ozone exposure (p < 0.1 or p < 0.05) when compared to matching air group. †Significant effect of maternal HFD (p < 0.1 or p < 0.05) when compared to matching maternal control diet (CD) group. Schematics of how microbiome can influence the production of 4-ethylphenyl sulfate from tyrosine (G), and how gut microbiome can change production of amino acid intermediates to produce catechol sulfate (H).

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