Table 2 OPLS-DA-derived VIP-plot detected chemical shifts responsible for the separation of 1D 1H NMR spectral data of 8 h fasted plasma samples from obese controls (n = 50) and obese T2DM (n = 50) patients.
Metabolite name | Chemical shift (δ) and type | P-value (Increased ↑) or (decreased ↓) |
|---|---|---|
β-hydroxybutyrate | 1.18 (d) | 0.009 (↑) |
Acetate | 1.9 (s) | 0.042 (↓) |
TMAO | 3.26 (s) | 2.61E-06 (↑) |
Taurine | 3.4 (t) | 0.004 (↑) |
d-Glucose | 3.46 (m), 3.38 (m), 3.62 (d), 3.82 (m), 3.72 (m) | 7.49E-12 (↑) |
Leucine | 1.7 (m), 3.7 (m) | 0.003 (↑) |
Isoleucine | 3.66 (d), 0.98 (d) | 4.36E−10 (↑) |
1, 3, 7-Trimethyl uric acid | 3.34 (s), 3.39 (s) | 0.002 (↑) |
Glycerol | 3.58 (dd) | 6.27E−07 (↑) |
TMAO | 3.26 (s) | 2.61E−06 (↑) |
Thymidine | 3.7 (m), 4.01 (q) | 0.004 (↑) |
Alanine | 1.46 (d), 3.75 (q) | 7.98E−12 (↓) |
Cholesterol | 0.86 (dd), 0.90 (d), 1.82 (d), 1.32(s), 1.5 (s) | 0.017 (↓) |
Malonate | 3.1 (s) | 0.019 (↑) |
α-Lactate | 4.1 (m), 1.3 (m) | 0.026 (↓) |
Hexanoylcarnitine | 0.86 (t) | 0.037 (↓) |
Uridine | 4.34 (dd) | 0.018 (↓) |
Cholesterol sulfate | 0.66 (m), 0.94 (m), 1.78 (m) | 0.036 (↓) |
Uric acid | 3.1 (t) | 0.031 (↑) |
