Figure 4

Correlation between F. nucleatum, LINE-1- and patients age in tumorous tissue of GC patients. (A) Correlation between Fusobacterium spp. abundance in T-GC and patients age in GC patients (n = 81, p = 0.025). (B) Correlation between F. nucleatum abundance in T-GC and patients age in GC patients (n = 80, p = 0.0031). (C) Differences in F. nucleatum abundance based on the patients age defined as below or above median age (68 years). (D) Correlation between F. nucleatum and LINE-1 DNA methylation in T-CRC specimens (n = 80, p = 0.153). (E) LINE-1 DNA methylation differences between F. nucleatum-positive (n = 23) and –negative (n = 57) T-GC (p = 0.09). Mann–Whitney and Spearman’s tests were used for analysis.