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Figure 1

From: Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Figure 1

Effects of trigonelline (TGN) on axonal and dendrite growth in amyloid β (Aβ)-treated cortical neurones. (A) Time course of the experiment (B,C) Mouse cortical neurones were cultured for three days and then treated with Aβ25-35 (10 µM) with or without TGN (1 or 10 µM) or vehicle solution. After 4 days of treatment, the axons and dendrites were immunostained. Phosphorylated neurofilament-H (pNF-H) and microtubule-associated protein 2 (MAP2) were stained as axonal and dendritic markers, respectively. The statistical analysis was performed using a one-way analysis of variance (ANOVA) and post hoc Dunnett’s test, *P < 0.05, **P < 0.01, ****P < 0.0001 versus Aβ25-35 /Veh, n = 18–19 areas.

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