Figure 1
Objective measurement of MCCL and shows a discrepancy with visual measurement and pathologist estimation. (A) MCCL difference between visual and digital MCCL shows under-estimation in visual compared to digital MCCL. Bar plot of visual MCCL in yellow and digital MCCL in blue, organised by Gleason score. MCCL is plotted on the y-axis; each patient is plotted on the x-axis. Red dashed lines represent a threshold of 6 mm as the MCCL criterion for significance (PROMIS definition 1). Patients highlighted in red were over or underestimated in the original visual measurement. (B) Waterfall plot representing the difference between visual and digital measurements as digital MCCL-visual MCCL by Gleason score (y-axis), patients plotted on the x-axis. Visual Gleason score is represented in yellow for 3 + 4 and blue for 4 + 3. Bars with a negative value represent measurements where the visual MCCL was shorter than the digital MCCL (underestimation). Bars with a positive value represent cases were the visual MCCL was higher than the digital MCCL. The difference in 80% of cases is ± 2 mm (n = 24), red dashed line at − 2 and 2 mm difference. (C) Density plots representing the MCCL distribution between visual and digital images by Gleason scores. Y-axis represents the Kernel density estimation. The X-axis contains MCCL values. Visual MCCL score is represented in yellow and blue for the digital measurement. 4 + 3.The mean visual MCCL was 9.53 mm (5–15 mm) and the mean digital MCCL was 9.88 mm (5.01–15.74).
